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New York, NY: WebMD. Last updated November 3, 2016. First Aid for the usmle Step. These immature cells continue to reproduce and build. Accessed April 14, 2017. Harrison's Principles of Internal Medicine.
During this phase, your white blood cells can still fight infections in your body. The granulocytes produced are fully functional. Cancer starts when cells in the body start to grow out of control. Lymphocytic (also known as lymphoid or lymphoblastic leukemias) start in cells that become lymphocytes. In: Chronic Myelogenous Leukemia Staging. Treatment Targeted therapy: first-line for chronic and accelerated phase Tyrosine kinase inhibitors : imatinib, nilotinib, dasatinib Nilotinib and dasatinib are new inhibitors that have shown an advantage over imatinib in some studies. The Biology of Chronic Myeloid Leukemia. CML occurs mostly in adults, but very rarely it occurs in children, too. Anemia, thrombocytopenia, thrombocytosis, decreased megakaryocytes, basophilia, myelofibrosis (increased reticulin or collagen). To learn more about how cancers start and spread, see. The accelerated phase is characterized by complications secondary to the suppression of the other cell lines ( thrombocytopenia, anemia, recurrent infections).